VACCINATION AGAINST SMALLPOX 185 



ject that was brought forward respecting what I had observed 

 in this neighbourhood 1 I perceive, by a reference since made 

 to the Memoirs of the Medical Society of London, may be 

 considered as no more than a corroboration of the facts very 

 clearly detailed by Mr. Kite.* To this copious evidence I have 

 to add still more in the following communications from Mr. 

 Earle, surgeon, of Frampton-upon-Severn, in this county, 

 which I deem the more valuable, as he has with much candour 

 permitted me to make them public : 



"SiR: 



' I have read with satisfaction your late publication on the 

 Variolae Vaccinae, and being, among many other curious cir- 

 cumstances, particularly struck with that relating to the in- 

 efficacy of smallpox matter in a particular state, I think it 

 proper to lay before you the following facts which came 

 within my own knowledge, and which certainly tend to 

 strengthen the opinions advanced in pages 56 and 57 of 

 your treatise. 



" In March, 1784, a general inoculation took place at 

 Arlingham in this county. I inoculated several patients with 

 active variolous matter, all of whom had the disease in a 

 favourable way ; but the matter being all used, and not being 

 able to procure any more in the state I wished, I was under 

 the necessity of taking it from a pustule which, experience 

 has since proved, was advanced too far to answer the pur- 

 pose I intended. Of five persons inoculated with this last 

 matter, four took the smallpox afterwards in the natural 

 way, one of whom died, three recovered, and the other, being 

 cautioned by me to avoid as much as possible the chance of 

 catching it, escaped from the disease through life. He died 

 of another disorder about two years ago. 



"Although one of these cases ended unfortunate, yet I 

 cannot suppose that any medical man will think me careless 

 or inattentive in their management; for I conceive the ap- 

 pearances were such as might have induced any one to sup- 



1 Inquiry into the Causes and Effects of the Variohe Vaccinz, p. 56 of the 

 original article. 



* See an account of some anomalous appearances consequent to the inocu- 

 lation of the smallpox, by Charles Kite. Suraeon, of Gravesend, in the 

 Mcmirs of the Medical Society of London, vol. iv, p. 114. 



