VACCINATION AGAINST SMALLPOX 195 



house, in this county, about Michaelmas last, and con- 

 tinued gradually to pass from one cow to another till the 

 end of November. On the twenty-sixth of that month 

 some ichorous matter was taken from a cow and dried upon 

 a quill. On the 2d of December some of it was inserted 

 into a scratch, made so superficial that no blood appeared, 

 on the arms of Susan Phipps, a child seven years old. The 

 common inflammatory appearances took place in conse- 

 quence, and advanced till the fifth day, when they had so 

 much subsided that I did not conceive any thing further 

 would ensue. 



6th: Appearances stationary. 



7th: The inflammation began to advance. 



8th: A vesication, perceptible on the edges, forming, as 

 in the inoculated smallpox, an appearance not unlike a grain 

 of wheat, with the cleft, or indentation in the centre. 



9th : Pain in the axilla. 



loth: A little headache; pulse, no; tongue not discol- 

 oured; countenance in health. 



nth, I2th: No perceptible illness; pulse about 100. 



I3th: The pustule was now surrounded by an efflores- 

 cence, interspersed with very minute confluent pustules to 

 the extent of about an inch. Some of these pustules ad- 

 vanced in size and maturated. So exact was the resem- 

 blance of the arm at this stage to the general appearance 

 of the inoculated smallpox that Mr. D., a neighbouring 

 surgeon, who took some matter from it, and who had never 

 seen the cow-pox before, declared he could not perceive any 

 difference. 7 The child's arm now shewed a disposition to 

 scab, and remained nearly stationary for two or three days, 

 when it began to run into an ulcerous state, and then com- 

 menced a febrile indisposition accompanied with an in- 

 crease of axillary tumour. The ulcer continued spreading 

 near a week, during which time the child continued ill, when 



T That the cow-pox was a supposed guardian of the constitution from the 

 action of the smallpox hail been a prevalent idea for a long time past; but 

 the similarity in the constitutional effects between one disease and the other 

 could never have been so accurately observed had not the inoculation of the 

 ow-pox placed it in a new and stronger point of view. This practice, too, 

 has shewn us, what before lay concealed, the rise and progress of die 

 pustule formed by the insertion of the virus, which placet in a most con- 

 spicuous light its striking resemblance to the pustule formed from the 

 inoculated smallpox. 



