196 EDWARD JENNER 



it increased to a size nearly as large as a shilling. It be- 

 gan now to discharge pus; granulations sprang up, and it 

 healed. This child had before been of a remarkably sickly 

 constitution, but is now in very high health. 



Mary Hearn, twelve years of age, was inoculated with 

 matter taken from the arm of Susan Phipps. 



6th day: A pustule beginning to appear, slight pain in the 

 axilla. 



7th: A distinct vesicle formed. 



8th: The vesicle increasing; edges very red; no deviation 

 in its appearance at this time from the inoculated .smallpox. 



9th: No indisposition; pustule advancing. 



loth: The patient felt this evening a slight febrile attack. 



nth: Free from indisposition. 



1 2th, 1 3th: The same. 



I4th: An efflorescence of a faint red colour extending 

 several inches round the arm. The pustule, beginning to 

 shew a disposition to spread, was dressed with an ointment 

 composed of hydrarg. nit. rub. and ung. ceres. The efflores- 

 cence itself was covered with a plaster of ung. hydr. fort. In 

 six hours it was examined, when it was found that the 

 efflorescence had totally disappeared. 



The application of the ointment with the hydr. nit. rub. 

 was made use of for three days, when, the state of the 

 pustule remaining stationary, it was exchanged for the ung. 

 hydr. nit. This appeared to have a more active effect than 

 the former, and in two or three days the virus seemed to be 

 subdued, when a simple dressing was made use of; but the 

 sore again shewing a disposition to inflame, the ung. hydr. 

 nit. was again applied, and soon answered the intended 

 purpose effectually. The girl, after the tenth day, when, as 

 has been observed, she became a little ill, shewed not the 

 least symptom of indisposition. She was afterwards ex- 

 posed to the action of variolous matter, and completely re- 

 sisted it. Susan Phipps also went through a similar trial. 

 Conceiving these cases to be important, I have given them 

 in detail: first, to urge the precaution of using such means 

 as may stop the progress of the pustule; and, secondly, to 

 point out (what appears to be the fact) that the most 

 material indisposition, or at least that which is felt most 





