VACCINATION AGAINST SMALLPOX 209 



"Dr. Lister, who was formerly physician to the Smallpox 

 Hospital, attended the child with me, and he is convinced that 

 it is not possible to give him the smallpox. I think the sub- 

 stituting the cow-pox poison for the smallpox promises to be 

 one of the greatest improvements that has ever been made 

 in medicine; and the more I think on the subject, the more 

 I am impressed with its importance. 



"With great esteem 

 "I am, etc., 



"HENRY CLINE. 



"Lincoln's Inn Fields, 

 August 2, 1798." 



From communications, with which I have been favoured 

 from Dr. Pearson, who has occasionally reported to me the 

 result of his private practice with the vaccine virus in 

 London, and from Dr. Woodville, who also has favoured 

 me with an account of his more extensive inoculation 

 with the same virus at the Smallpox Hospital, it appears 

 that many of their patients have been affected with erup- 

 tions, and that these eruptions have maturated in a man- 

 ner very similar to the variolous. The matter they made 

 use of was taken in the first instance from a cow be- 

 longing to one of the great milk farms in London. Having 

 never seen maturated pustules produced either in my own 

 practice among those who were casually infected by cows, 

 or those to whom the disease had been communicated by 

 inoculation, I was desirous of seeing the effect of the mat- 

 ter generated in London, on subjects living in the country. 

 A thread imbrued in some of this matter was sent to me, 

 and with it two children were inoculated, whose cases I 

 shall transcribe from my notes. 



Stephen Jenner, three years and a half old. 



3d day: The arm shewed a proper and decisive inflam- 

 mation. 



6th: A vesicle arising. 



7th : The pustule of a cherry colour. 



8th: Increasing in elevation. A few spots now appear 

 on each arm near the insertion of the inferior tendons 

 of the biceps muscles. They are very small and of a 



