VACCINATION AGAINST SMALLPOX 211 



These children were afterwards fully exposed to the 

 smallpox contagion without effect. 



Having been requested by my friend, Mr. Henry Hicks, 

 of Eastington, in this county, to inoculate two of his chil- 

 dren, and at the same time some of his servants and the 

 people employed in his manufactory, matter was taken 

 from the arm of this boy for the purpose. The num- 

 bers inoculated were eighteen. They all took the infec- 

 tion, and either on the fifth or sixth day a vesicle was 

 perceptible on the punctured part. Some of them began 

 to feel a little unwell on the eighth day, but the greater 

 number on the ninth. Their illness, as in the former cases 

 described, was of short duration, and not sufficient to in- 

 terrupt, but at very short intervals, the children from their 

 amusements, or the servants and manufacturers from fol- 

 lowing their ordinary business. 



Three of the children whose employment in the manu- 

 factory was in some degree laborious had an inflammation 

 on their arms beyond the common boundary about the 

 eleventh or twelfth day, when the feverish symptoms, which 

 before were nearly gone off, again returned, accompanied 

 with increase of axillary tumour. In these cases (clearly 

 perceiving that the symptoms were governed by the state 

 of the arms) I applied on the inoculated pustules, and 

 renewed the application three or four times within an 

 hour, a pledget of lint, previously soaked in aqua lythargyri 

 acetati and covered the hot efflorescence surrounding them 

 with cloths dipped in cold water. 



The next day I found this simple mode of treatment 

 had succeeded perfectly. The inflammation was nearly 

 gone off, and with it the symptoms which it had pro- 

 duced. 



Some of these patients have since been inoculated with 

 variolous matter, without any effect beyond a little in- 

 flammation on the part where it was inserted. 



Why the arms of those inoculated with the vaccine mat- 

 ter in the country should be more disposed to inflame than 

 those inoculated in London it may be difficult to determine. 

 From comparing my own cases with some transmitted to 



"Goulard'f extract of Saturn. 



