VACCINATION AGAINST SMALLPOX 225 



suspending the progress of the smallpox after the patients 

 had been several days casually exposed to the infection have 

 been laid before me by Mr. Lyford, Surgeon, of Winchester, 

 and my nephew, the Rev. G. C. Jenner. Mr. Lyford, after 

 giving an account of his extensive and successful practice in 

 the vaccine inoculation in Hampshire, writes as follows: 



"The following case occurred to me a short time since, 

 and may probably be worth your notice. I was sent for to 

 a patient with the smallpox, and on inquiry found that five 

 days previous to my seeing him the eruption began to appear. 

 During the whole of this time two children who had not 

 had the smallpox, were constantly in the room with their 

 father, and frequently on the bed with him. The mother 

 consulted me on the propriety of inoculating them, but object- 

 ed to my taking the matter from their father, as he was 

 subject to erysipelas. I advised her by all means to have 

 them inoculated at that time, as I could not procure any 

 variolous matter elsewhere. However, they were inoculated 

 with vaccine matter, but I cannot say I flattered myself with 

 its proving successful, as they had previously been so long 

 and still continued to be exposed to the variolous infection. 

 Notwithstanding this I was agreeably surprised to find the 

 vaccine disease advance and go through its regular course; 

 and, if I may be allowed the expression, to the total extinction 

 of the smallpox." 



Mr. Jenner's cases were not less satisfactory. He writes 

 as follows: 



"A son of Thomas Stinchcomb, of Woodford, near Berke- 

 ley, was infected with the natural smallpox at Bristol, and 

 came home to his father's cottage. Four days after the erup- 

 tions had appeared upon the boy, the family (none of which 

 had ever had the smallpox), consisting of the father, mother, 

 and five children, was inoculated with vaccine virus. On the 

 arm of the mother it failed to produce the least effect, and 

 she, of course, had the smallpox, 8 but the rest of the family 

 had the cow-pox in the usual way, and were not affected 

 with the smallpox, although they were in the same room, 

 and the children slept in the same bed with their brother 



Under similar circumstances I think it would be advisable to insert the 

 matter into each arm, which would be more likely to insure the success of 

 the operation. E. J. 



(8) HC XXXVIII 



