228 EDWARD JENNER 



who was confined to it with the natural smallpox; and sub- 

 sequently with their mother. 



"I attended this family with my brother, Mr. H. Jenner." 

 The following cases are of too singular a nature to remain 

 unnoticed. 



Miss R , a young lady about five years old, was seized 



on the evening of the eighth day after inoculation with vac- 

 cine virus, with such symptoms as commonly denote the acces- 

 sion of violent fever. Her throat was also a little sore, and 

 there were some uneasy sensations about the muscles of the 

 neck. The day following a rash was perceptible on her face 

 and neck, so much resembling the efflorescence of the scarla- 

 tina anginosa that I was induced to ask whether Miss R 



had been exposed to the contagion of that disease. An an- 

 swer in the affirmative, and the rapid spreading of the redness 

 over the skin, at once relieved me from much anxiety respect- 

 ing the nature of the malady, which went through its course 

 in the ordinary way, but not without symptoms which were 

 alarming both to myself and Mr. Lyford, who attended with 

 me. There was no apparent deviation in the ordinary prog- 

 ress of the pustule to a state of maturity from what we see 

 in general ; yet there was a total suspension of the areola or 

 florid discolouration around it, until the scarlatina had retired 

 from the constitution. As soon as the patient was freed from 

 this disease this appearance advanced in the usual way.* 



The case of Miss H R is not less interesting than 



that of her sister, above related. She was exposed to the 

 contagion of the scarlatina at the same time, and sickened 

 almost at the same hour. The symptoms continued severe 

 about twelve hours, when the scarlatina-rash shewed itself 

 faintly upon her face, and partly upon her neck. After re- 

 maining two or three hours it suddenly disappeared, and she 

 became perfectly free from every complaint. My surprise 

 at this sudden transition from extreme sickness to health in 

 great measure ceased when I observed that the inoculated 

 pustule had occasioned, in this case, the common efflorescent 



I witnessed a similar fact in a case of measles. The pustule from the 

 tow-pock virus advanced to maturity, while the measles existed in the con- 

 stitution, but no efflorescence appeared around it until the measles had ceased 

 to exert its influence. 







