VACCINATION AGAINST SMALLPOX 229 



exercises, it is possible that these anomalous appearances 

 might owe their origin to the friction of the clothes on the 

 newly inflamed part of the arm. I have not yet had an 

 opportunity of exposing them to the smallpox. 



In the early part of this inquiry I felt far more anxious 

 respecting the inflammation of the inoculated arm than at 

 present ; yet that this affection will go on to a greater extent 

 than could be wished is a circumstance sometimes to be ex- 

 pected. As this can be checked, or even entirely subdued, by 

 very simple means, I see no reason why the patient should 

 feel an uneasy hour because an application may not be abso- 

 lutely necessary. About the tenth or eleventh day, if the 

 pustule has proceeded regularly, the appearance of the arm 

 will almost to a certainty indicate whether this is to be ex- 

 pected or not. Should it happen, nothing more need be done 

 than to apply a single drop of the aqua lythargyri acetat? 

 upon the pustule, and, having suffered it to remain two or 

 three minutes, to cover the efflorescence surrounding the pus 

 tule with a piece of linen dipped in the aqua lythargyri 

 compos. 9 The former may be repeated twice or thrice during 

 the day, the latter as often as it may feel agreeable to the 

 patient. 



When the scab is prematurely rubbed off (a circumstance 

 not unfrequent among children and working people), the 

 application of a little aqua lythargyri acet. to the part imme- 

 diately coagulates the surface, which supplies its place, and 

 prevents a sore. 



In my former treatises on this subject I have remarked 

 that the human constitution frequently retains its susceptibil- 

 ity to the smallpox contagion (both from effluvia and contact) 

 after previously feeling its influence. In further corrobora- 

 tion of this declaration many facts have been communicated 

 to me by various correspondents. I shall select one of them. 



"DEAR SIR: 



" Society at large must, I think, feel much indebted to 

 you for your Inquiries and Observations on the Nature and 

 Effects of the Variolae Vaccinae, etc., etc. As I conceive 



Extract of Saturn. 



Goulard water. For further information on this subject see the first 

 Treatise on the Var. Vac., Dr. Marshall's letters, etc. 



