106 Botanic Drugs 



examination with atropine, physostigmine may be 

 instilled to relieve the intra-ocular pressure induced. 

 The technic of the ophthalmic uses are important, 

 as harm may be done if one ventures incautiously. 

 Consult works on ophthalmology. 



EUMYDRIN is the nitrate of methylated atropine 

 and is mydriatic and antihidrotic. It is used like 

 atropine, but is claimed to be less toxic, internal 

 doses ranging from 1-60 to 1-24 grain, and as a 

 mydriatic one-tenth stronger than the usual 

 atropine solutions. ETJPHTHALMIN is a combina- 

 tion of maudelic acid and a base similar to that 

 contained in beta-eucaine; it is a synthetic analogue 

 of atropine and resembles it in effect, but is used 

 only in ophthalmic work. It is claimed not to 

 increase intra-ocular tension. 



BERBERIS 



OREGON GRAPE, MOUNTAIN GRAPE, Herberts aqui- 

 folium. Official in U. S. P. Eighth Rev. Herberts 

 Artstata official in England. Herberts vulgarts, BAR- 

 BERRY, official in France. 



PHARMACOLOGY. Hydrastis and berberis are al- 

 lied and will be discussed in detail under "Hydrastis" 

 (q. v.). However, it may be said that BERBERINE 

 has little action in small doses. In large doses it 

 causes vaso-dilatation and cardiac depression, with 

 reduced blood-pressure. There is no useful field for 

 berberis in large doses. In small doses it is a useful 

 simple bitter. In large doses it is a gastro-intestinal 

 irritant; and alterative properties have been claimed 

 for drugs of that class, but usually upon no secure 

 basis. There is no evidence that berberis possesses 

 alterative properties in doses that are advisable. 



