Botanic Remedies 195 



there are clinical points of dissimilarity, that one 

 should no more over-use hyoscyamine than he should 

 atropine. Scopolamine is almost identical with 

 hyoscine. Its now largely discredited vogue in the 

 so-called "twilight sleep" brought it into undue 

 notice. Physicians who care to run the risk of 

 "twilight sleep" methods should first carefully 

 study special books upon the subject. 



ADMINISTRATION. The tincture is given in doses 

 of 5 to 20 minims; the extract, in an average dose of 

 1 grain; the fl., in doses of 1 to 5 minims, average 3 

 minims. The alkaloids are: Scopolamine hydrobro- 

 mide U. S. P. (average dose, 1-200 grain), hyoscine 

 hydrobromide (8th Rev., av. dose 1-128 grain), 

 hyoscyamine hydrobromide, U. S. P. (av. dose, 1-200 

 grain), and hyoscyamine sulphate (8th Rev., av. 

 dose 1-128 grain). Note the tendency of the U. S. P. 

 IX for lower dosage. 



Merck's Manual lists hyoscine (from various 

 solanaceae). Dose for insane, 1-30 grain; for sane 

 persons, 1-400 to 1-200 grain. Hydrobromide in 

 same doses. Hyoscyamine alkaloid (from hyoscy- 

 amus) in crystalline form. Dose for insane, 1-8 to 

 % grain; for sane persons, 1-120 to 1-30 grain. An 

 amorphous form of this alkaloid is in the form of a 

 syrupy liquid, and is used in doses of 1-8 to ^ minim. 

 And a sulphate of the amorphous alkaloid is used 

 in doses of 1-8 to % grain, whereas the sulphate of 

 the crystalline alkaloid is only 1-120 to 1-30 grain 

 in dosage. 



Scopolamine hydrobromide (Merck), dose 1-240 to 

 1-60 grain; for general anesthesia, 1-100 to 1-60 

 grain with 1-6 grain morphine hydrochloride, every 

 hour for three doses. 



