274 Botanic Drugs 



drug is of value. Binz was the main advocate of 

 the use of quinine in the treatment of whooping 

 cough. He gave the hydrochioride in doses of 1-6 to 

 2 grains in the course of twenty-four hours to a 

 child under one year of age, 3 grains during twenty- 

 four hours at two years of age, 4^2 grains at three 

 years, 6*4 at four years, 7% at five years, and 15^ 

 at ten years, all of these being twenty-four hour 

 dosage. 



Quinine kills the malarial parasite; it is a specific 

 prophylactic and curative agent in malarial fever, 

 or, as it is now known, "mosquito fever" As a 

 prophylactic enough must be kept in the circulation 

 to inhibit the development of the Plasmodium 

 malariae, usually from 5 to 15 grains a day, though 

 more is required in a malarial district. 



As a curative agent, quinine should be so admin- 

 istered as to be in greatest concentration in the 

 blood just before the sporulation of the parasite 

 occurs, when it is least resistant. A large dose 

 (10 to 15 grains) should be given thrice daily for 

 two days before the expected onset of the paroxysm, 

 the last dose being administered about six hours 

 before that event; then continue in smaller dosage. 

 Small and divided doses should not be continued 

 for long, however, the effort being made to meet 

 the next paroxysm with adequate dosage. It is 

 necessary to give opium to some persons, with these 

 large doses of quinine, in order to limit gastric dis- 

 tress. Arsenic and smaller doses of quinine should 

 be given during the interval. 



In remittent fever, give from 20 to 30 grains in a 

 single dose once or twice in a day until the tem- 

 perature falls to about normal. In pernicious 



