THRUSH 237 



On Agar it forms white tufts somewhat puckered (see Photograph, 

 Fig. 87), while the deeper underlying portions are of a yellowish colour. 



On Blood Serum, white tufts ; the medium is liquefied. 



On Potatoes, a slow growth. 



In contradistinction to other fungi, the cultures retain their vitality 

 for a long time. 



Pathogenesis. The artificial production of Herpes tonsurans with 

 material containing gonidia has taken place. 



Sabouraud distinguishes two groups of trichophyton which he classi- 

 fies as Botrytis tonsurans, characterised by the grape form arrangement 

 of the fruit. Both groups are distinguished by the size of their spores, 

 and according to Sabouraud, are named Trichophyton microsporon and 

 megalosporon. 



The first form affects only hairy places, and its spores are 3 //, in 

 diameter. It causes the severe affection in children known as the 

 Maladie de Gruby. 



The second form has spores from 7 to 8 /x in diameter, and causes 

 in adults a trichophyton affection of the beard as well as of bald parts 

 of the body. According to Sabouraud the trichophyton affecting man 

 and animals exhibit well-marked morphological and clinical differentia- 

 tion ; and furthermore, he states that the trichophyton microsporon when 

 grown on potatoes, in contradistinction to all other varieties which die 

 after three weeks on that media, continues to grow slowly, and after 

 three months further cultures can be instituted in fresh media from the 

 original. 



THRUSH. 



This disease is caused by a fungus, the Old-turn albicans, and occurs 

 on all mucous membranes with squamous epithelium, especially in the 

 mouths of infants, where it is manifested by white patches. 



Microscopical Appearances. Sometimes mycelial threads are 

 present, and at other times round or oval conidia like yeast cells. 



Biological Characters. Strongly aerobic ; optimum tempera- 

 ture, 37 C. 



On Gelatine Plates, white, non-liquefying colonies. 



On Gelatine Stab Cultures, yellow-white grains, with processes extend- 

 ing into the medium. 



On Agar, a yellowish-white growth. 



On Potatoes, a thick white coating, which frequently is observed to 

 consist of small clusters. 



On Bread Paste, a thin white coating. 



In Media containing Sugar or Acid Media it grows more in the form 

 of buds or yeast-like cells. 



