INFANTILE PARALYSIS 669 



that the virus is a filter-passer, and is present in the 

 central nervous system, the gasserian and some of the 

 other ganglia, in the salivary and some of the lymphatic 

 glands, and sometimes in the blood. 



Injection of emulsions of the affected cord into the 

 brain, spinal cord, peritoneal cavity, and blood-stream 

 of monkeys reproduces the disease with the same clinical 

 and pathological features as in man. The disease can 

 be carried on from monkey to monkey by inoculation, 

 but does not seem to be transmissible to other animals. 

 Remarkable fluctuations in the virulence of the virus 

 may occur. 



Flexner has observed a case of spontaneous infection 

 in the monkey, and found that the naso-pharyngeal 

 mucosa was infective, so that this is probably the Channel 

 of infection in man. Flies belonging to the genus Stom- 

 oxys are stated to be capable of transmitting infection. 

 Human cerebro -spinal fluid was not found infective in 

 some instances, but monkey cerebro-spinal fluid is 

 infective (infectivity in this case may depend on the stage 

 of the disease). 



Human ascitic fluid inoculated with the filtered fluid 

 from emulsions of cord became turbid, but no organism 

 could be detected microscopically, and the culture can 

 be carried on from tube to tube (Flexner and Noguchi). 

 Monkeys which have recovered from an attack are refrac- 

 tory to inoculation. A certain degree of active immunity 

 may be established by subcutaneous injection of the 

 virus. The serum of immunised and recovered animals 

 possesses considerable neutralising power for the virus. 

 Attempts are now being made to prepare a curative 

 serum. 



Some cases of the acute ascending paralysis of Landry 

 may be forms of this disease (see also p. 661). 



Buzzard, from a case of the latter disease, isolated 



