535 



entire faces, including the nasal bones, were eaten away by rapid 

 ulceration. Tubercles were found in the lungs. 



A pack of wolves in the Philadelphia Zoological Garden died in ten 

 days after being fed with the meat of a glandered liorse. The rabbit, 

 Guinea pig, and mice are specially susceptible to the inoculation of 

 glanders, and the recent discoveries in regard to this disease have 

 made these animals most convenient witnesses and proofs of the exist- 

 ence of suspected cases of the glanders in other animals by the results 

 of successful inoculations. 



The sheep and the goat are both capable of developing the disease. 

 The goat is more susceptible and frequently develops it by means of 

 the digestive tract, from its habit of eating droppings, i-ags, etc. , which 

 are found in the neighborhood of the stall. The pig is considered not 

 to be susceptible to glanders, and a large number of inoculations, 

 together with the feeding of glandered meat to a pen of pigs at the vet- 

 erinary school at Alfort, failed to give these animals the disease, but 

 Bollinger reports that Gerlach has seen glanders in the pig nine 

 months after inoculation. An experiment of Spinola has also pro- 

 duced positive results, so that we should consider it dangerous to allow 

 a pig the use of glandered meat. 



Horned cattle and barnyard fowls are absolutely exempt from 

 attacks of glanders, whether the virus is given to them by the digest- 

 ive tract or inoculated into their tissues. 



The previous reference to the existence of glanders under the two 

 forms more commonly differentiated as glanders and as farcy, and our 

 reference to the various conditions in which it may exist as acute, 

 chronic, and latent, show that the disease may assume several differ- 

 ent phases. Without losing sight for a moment of the fact that all of 

 these varied conditions are identical in their origin and in their 

 essence, for convenience of study we may divide glanders into three 

 classes: Chronic farcy, chronic glanders, and acute farcij glanders. 



The primary lesions in any form is a local point of eruption in which 

 we have a rapid prolification of the cell elements which make up the 

 animal tissue with formation of new connective tissue, with a crowd- 

 ing together of the elements until their own pressure on each other 

 cuts off the circulation and nutrition, and death takes place in them 

 in the form of idceration or gangrene. Following this primary lesion 

 we have an extension of infection by means of those tissues immedi- 

 ately surrounding the first infected spot, which is most suitable for the 

 development of simple inflammatory phenomena or the specific virus. 

 Tlie primary symptoms are the result of inoculation developed at the 

 point of inoculation, but at a later time the virus is carried by means 

 of the blood vessels and lymphatic vessels to other parts of the body 

 and becomes lodged at different places and develops in them; again, 

 when the disease has existed in the latent form in the lungs of the 

 animal and tho virus is Avakened into action from any cause, we have 



