-en. 



H. 



Fig. 39- 



Figures illustrating the stages of the life cycle of the malarial parasite found 

 in Anopheles. A, crescent-shaped gametocytes of Plasmodium i>n- 

 maculatum of pernicious tropical malaria ; $ the microgametocy te ; 

 $ the macrogametocyte. , further stages in the development of <$ 

 the microgametocyte and ^ the macrogametocyte of Plasmodium 

 vivax ; the nucleus of the macrogametocyte has divided unequally to 

 form a polar body, pb. C, the nucleus of the microgametocyte has 

 broken up into eight karyosomes, ky, each surrounded by a ring of 

 chromatin granules ; the polar body has separated from the macro- 

 gametocyte. I), formation of microgametes from the microgametocyte. 

 , a single microgamete ; ky t the central karyosome. f, fertilisation 

 of the macrogamete by the microgamete ; n $ , male pronucleus ; n $? 

 female pronucleus. G, the motile zygote or ookinete ; en, fertilisation 

 nucleus. //, the ookinete (oocyst) surrounded by a very delicate cyst 

 wall, at rest in the tissues of the wall of the stomach of the mosquito ; 

 , nucleus ; /, pigment. _/, multiplication of nuclei in the oocyst. A", 

 the protoplasm of the oocyst has divided into numerous sporoblasts, 

 sp. (>l, each containing a nucleus. L, early formation of sporozoites 

 from the sporoblasts. Af, a ripe oocyst full of minute sporozoites, spz, 

 which are escaping by the bursting of the cyst ; rp, residual protoplasm 

 containing an abortive nucleus (B-G after Schaudinn, the remaining 



