20 THE PITUITARY GLAND 



The animal, after a total removal, shows no devia- 

 tion from the normal for a period varying from thirty- 

 six hours to two weeks after the operation. Then 

 it becomes unsteady, there is arching of the back, 

 low temperature, shivering, and death in uncon- 

 sciousness. 



Gushing has found it possible to effect partial 

 removals of the anterior lobe. In young animals, 

 the result , is that an "infantile" type is main- 

 tained, and the secondary sexual characters do not 

 develop. In older animals, the genitals atrophy, 

 and they get very fat. He gives very convincing 

 photographs showing that these changes are quite 

 marked. 



INJECTION OF EXTRACTS OF PITUITARY GLAND. 

 PITUITARY FEEDING. 



Injection of extracts of the anterior lobe causes 

 no evident results. Injection of extracts of the 

 posterior or nervous lobe causes quite constantly a 

 prolonged rise of blood-pressure. Not only the blood 

 vessels, but all varieties of unstriped muscle, are 

 stimulated to contract. Peristaltic movements are 

 set up in the bowel, and the bladder and uterus, 

 whether pregnant or not, also contract. 



Pituitary feeding in man causes diuresis. Indeed, 

 it is said to be our best available diuretic, and is 

 now on the market for that purpose. Its effect 

 is better seen when the urinary flow is diminished 

 than when it is normal. 



Pituitary feeding in young rats causes an exaggera- 

 tion of their growth. In this case it is not the 



