VIL] MICROCOCCUS. 47 



Burden Sanderson confirmed and extended this. 1 Colin 2 

 proved that the lymph of vaccinia and variola contains 

 numerous micrococci. Weigert 3 showed for human small -pox, 

 Klein 4 for sheep-pox, that the lymphatics of the skin in the 

 region of the pock are filled with micrococci, and Pohl-Pincus 5 

 traced their passage through the epidermis at the point of 



'''cv 



FIG. IS. MICROCOCCUS IN THE FRESH LYMPH uj? HUMAN SMALL-POX. 



1. Sinply. 



2. In dumb-bells. 



3. In shoit chains. 



vaccination in the calf. The micrococci are very minute, 

 according to Cohn's estimate 0'0005 mm. and less in diameter, 

 single or in dumb-bells, or in shorter or longer chains, or in 

 small groups. When cultivated on the warm stage, they form 

 very long chains and colonies. In connexion with this it 



FIG. 19. LYMPHATIC VESSEL FROM THE SKIN OK A POCK IN SHEEP-POX 

 The vessel is filled with micrococci. 



must be mentioned, as stated on a former page, that similar 

 micrococci occur also in the fluid contents of vesicles in the 

 skin produced by various non-infective inflammations. To 

 make it sure that the micrococci are the active principle, i.e. 

 the cavsa mnrbi, it would be necessary to artificially cultivate 

 them through several generations, and then, by re-inoculating 



1 Pevorts on the Intimate Patlwlony r>f Contagion. 



2 Virchow's Archir, 1872, Keber, H-llier, Ziirn. 3 Mediz. Centralbatt, 1S71. 

 4 PhiL Transact. 1S74. 5 Vaccination, Berlin, 18S2. 



