XL] BACILLUS : PATHOGENIC FORMS. 89 



bacilli containing spores were thicker than those without 

 them. 



Experiments by feeding and inoculation made on dogs and 

 cats, rabbits, guinea-pigs, and mice, with the ham that had 

 done the mischief in the Welbeck case produced positive 

 results. In all cases we found pneumonia and haemorrhage in 

 the liver, peritonitis in some, spleen enlarged in most. The 

 bacilli found in this ham were cultivated in the incubator in 

 white of egg, and after two days' cultivation four white rats, 

 and several guinea-pigs and white mice were inoculated, and 

 they became ill after twenty-four hours ; they were quiet, did 

 not feed well, and were more or less soporous. When killed 

 the spleen was found enlarged, and in the lungs were found 

 haemorrhage and hypersemia, and in some cases extensive 

 pneumonia. 



Blood, pericardial exudation, and lung juice from the fatal 

 Nottingham caseJnoculated into ten animals (guinea-pigs and 

 white mice) produced fatal results in six, the other four were 

 killed ; but in all there was severe pneumonia, in eight out of 

 the ten there was peritonitis, in four also pleuritis, and in two 

 in addition enlargement of the liver and spleen. Bacilli were 

 found in the blood and exudations of these animals. On 

 cultivating blood and lung juice from the above case, a crop of 

 bacilli was produced, which on inoculation proved very 

 poisonous in the same way as in the previous cases. 1 



(e) Bacillus rttalarice. Klebs and Tommasi-Crudeli 2 de- 

 scribed a bacillus occurring in the soil of the Roman Campagna, 

 which they cultivated on gelatine. The rods are about 0*002 

 to 0*007 mm. long ; they grow in cultures into long leptothrix 

 filaments composed of short joints. The rods form spores 

 eith'er in the centre or at their ends. They grow well also in 

 other media, e.g. albumen, urine, and glue. They require 

 oxygen for their growth, and are therefore aerobic. According 

 to Marchiafava, 3 they occur also in the blood of patients 

 suffering from malaria. Inoculations of rabbits with the 

 cultivated or original bacilli produced a febrile disorder, which 

 Klebs and Tommasi-Crudeli consider analogous to the human 

 intermittent fever ; but experiments made by Sternberg with 

 material derived from the soil of malarious localities in 

 America did not bear this out. The febrile disorder had 

 nothing of the character of human intermittent fever, and 



1 Compare also Hubcr, Archiv f. klin. Med. xxv. 

 '* Archiv f. txp. Path. vol. xi. 

 3 Archiv f. exp. Path. vol. xiii. 



