100 



MICRO-ORGANISMS AND DISEASE. [CHAP. 



Inoculation experiments on domestic animals and monkeys 

 have hitherto failed. 1 Damsch 2 maintains, however, that he 

 was able, by inoculation with leprous tissue into the peritoneal 

 cavity and into the skin, to produce in cats a distinct increase 

 and sprouting of the bacilli. Preparations of leprous nodules 

 of the larynx and skin made by my friend, Mr. A. Lingard, 

 and stained with Weigert's solution of magenta and vesuvin, 

 showed the leprosy-bacilli completely nllincf all the cells, 



FIG. (57. CELLS OF THF. LEPROSY NODULES OF MAN, FILLED WITH THE 

 LEPROSY BACILLI (AFTER NEISSER). 



small and large, spherical and spindle-shaped, contained 

 between the connective-tissue bundles. 



In a section through the liver of a bird (Eliea) that died in 

 the Zoological Gardens in London, prepared by Dr. Gibbes 

 after his method of staining for tubercle-bacilli, there were 

 seen innumerable aggregations of larger and smaller pink 

 masses (visible to the'unaided eye as dots of the size of a pin's 

 point to that of a pin's head or millet seed, and larger). Under 



FIG. 68. I'HuM AN AR'lIFTCTAI, ClTT.Tl'RK OF BACILLUS OF LEPROSY 



(AFTER NEISSER). 



the microscope these pink masses were seen to be composed of 

 cells of various sizes, each filled with an enormous number of 

 what appeared under a high power very short bacilli, much 

 shorter than tubercle-bacilli. But they gave the same re- 

 action as tubercle-bacilli. Here and there isolated cells of 

 various sizes could be seen filled with the bacilli. In the 

 large cells the cell-outline was becoming indistinct, and in 

 some the cell-substance was seen to break down, whereby the 



1 Kobner, Virchow's Archiv, vol. Ixxxviii. ; Hanscn, ibidem, vol. xc. 

 3 Virchow's Archiv, vol. xcii. 



