102 MICRO-ORGANISMS AND DISEASE. [CHAP. 



twenty-four to forty-eight hours. This form of septicaemia is 

 also called " Pasteur's septicaemia," and is of course distinct and 

 different from Davaine's septicaemia. 1 At the seat of the inocu- 

 lation and spreading from it into the subcutaneous tissue of 

 adjoining parts there is much discoloration and occasionally 

 haemorrhage ; a turbid offensively-smelling ichor fills the 

 spaces of the subcutaneous tissue, and in it are found large 

 numbers of bacilli, some motile, others not. The lungs are 

 hyperaDinic and have small ha?morrhngic spots. The spleen is 



Fix 71. BLOOD OP A GUINEA-PIG DEAD OF KOCH'S MALIGNANT (EDEMA. 



1. Red blood discs. 



2. White corpuscles. 



3. Single bacilli. 



4. Chain of long bacilli. 



5. Leptothrix. 



Magnifying power 700. (Stained with gentian violet.) 



invariably enlarged and haemorrhagic spots are often noticed 

 on the peritoneum of the abdominal organs, and there is some 

 peritoneal exudation. The blood of the spleen, of the liver, 

 lung, and intestine, the serous coating of the abdominal organs, 



1 Rosenberger maintains (Centralblatt f. d. med. Wiss. 4, 1883) that the blood 

 and exudation-fluids of rabbits dead of Davaine's or Pasteur's septicaemia can be 

 effectually sterilised by heat without losing their specific action, reproducing on 

 injection into fresh animals the disease with the recurrence of the organisms 

 characteristic of the disease. Dowdeswell, however, states (Proceedings of the 

 Royal Society, 221, 1882) that this is not the case, for on really effectual sterilisa 

 tion by heat the organisms are killed, and the fluids become innocuous. 



