XL] 



BACILLUS : PATHOGENIC FORMS. 



107 



these cases abrasions in the mucous membrane of the mouth, pharynx, or 

 gut, may have been the real place of entrance. Mice fed with anthrax material 

 do not become infected (Klein, ibid 1SS1). But the reported cases of intestinal 

 mycosis (see for the literature of this subject, Koch, " jEtiologied. Milzbrandes," 

 Mittheil. a. d. k. Gc&undheitsamte. 1881,) seem nevertheless to indicate that such 

 a mode of infection, namely, by the alimentary canal, is not excluded. Compare 

 also Falk, Virchow's Archiv, vol. xciii. 



Rodents inoculated with the bacillus of the blood or spleen 

 of an animal dead of anthrax, or with the bacillus or spores 

 of an artificial culture, die generally within forty-eight hours ; 

 in some instances in twenty-four to thirty hours, in other 

 exceptional instances after forty-eight to sixty hours. The 



Fro. 73. FROM A PREPARATION OF HEART'S BLOOD OF A O0iNEA-rio DEAD 

 OF ANTHRAX. 



1. Red blood-discs. 



2. White corpuscle. 



3. Bacilli anthracis. 



Magnifying power 700. (Stained with Spiller's pnrple.) 



blood in all instances contains the bacilli, the spleen is large 

 and full of bacilli, and so are the blood-vessels of most other 

 organs, the exudations, and the urine. In the placenta of a 

 pregnant guinea-pig dead in consequence of inoculated anthrax, 

 I have seen that the bacilli keep strictly as a rule within the 

 maternal blood-vessels, and are wholly absent in the blood of 

 the vessels of the foetus. Subcutaneous inoculation or injec- 

 tion into the cutis of the minutest quantity of bacillus-con- 

 taining material (blood or artificial culture) invariably produces 

 death. Subcutaneous injection of bacillus-containing material 

 in the guinea-pig almost always produces a characteristic 

 oedema, spreading sometimes over a large area. The cedematous 

 fluid is clear and contains only a few bacilli. 



