50 THE CONNECTIVE TISSUES, BY A. ROLLETT. 



the connective tissue question affected by the views which 

 were coincidently expressed by Max Schultze upon the solid 

 intercellular substances of the animal tissues. Up to that 

 time the majority of observers regarded the matrix of hyaline 

 cartilage as the prototype of an amorphous intercellular sub- 

 stance, and indeed very generally as the starting-point for its 

 consideration. Max Schultze, on the other hand, opposed to 

 this the hitherto little regarded views of Remak and Fiirsten- 

 burg, on the matrix of cartilage, and sought to show that we 

 have not here to deal with an intercellular substance in the 

 sense of a hardened secretion between the cells, but rather that 

 the so-called intercellular substance, from its very commence- 

 ment, proceeds from the protoplasm of the cells. This, in its 

 turn, immediately led to renewed investigation respecting the 

 genetic significance of the matrix of bone, and of the fibrillar 

 substance of connective tissue. 



Max Schultze* forthwith stated his opinion that the fibrillar 

 substance of connective tissue originates from "embryonal 

 cells composed of protoplasm, and destitute of any investing 

 membrane, which have amalgamated with one another." A thin 

 layer only of the protoplasm remains lying around the nucleus 

 of the primary cell, representing with this nucleus a connective 

 tissue cell, destitute of cell wall (connective tissue corpuscles). 

 It should also be mentioned that, quite independently of the 

 discussion maintained on these points in Germany, similar 

 views respecting the development of connective tissue were 

 expressed in England by Beale.f According to Beale's pecu- 

 liar terminology, connective tissue is originally composed of 

 elementary parts (cells), which consist of germinal matter 

 (Keimstoffe, protoplasm); but subsequently a part of the 

 germinal matter is converted into formed material (in con- 

 nective tissue the fibrillar substance), which was itself in the 

 first instance germinal matter, and was developed at the cost 

 of that matter. Beale, whose statements were of a -some- 

 what general nature, admitted a similar genetic relation 



* Loc. tit., p. 13. 



t The Structure of the Simple Tissues of the Human Body, translated 

 into German by V. Cams. Leipzig, 1862, pp. 36, 6, etc. 



