

ORIGIN OF THE LYMPH CORPUSCLES. 345 



caution. I have especially observed that not only colourless 

 cells escape from the blood path, but that migrating corpuscles 

 of the connective tissue penetrate into its interior. After their 

 entrance they creep along with long processes applied to the wall, 

 in order again to escape at another point. What should we say 

 if, in the above observations upon the mesentery, the escaping 

 cells prove to be only such penetrating cells, which have entered 

 either at a neighbouring point of the vascular wall (either of a 

 vein or a capillary), or perhaps have crept on to a more distant 

 point in the arteries, or have originally been formed in the sur- 

 rounding tissue ? 



Whether the lymph corpuscles and the migrating connective 

 tissue cells originate in the place where they are met with, 

 and become converted into immovable connective tissue cor- 

 puscles, as I have already stated is not impossible, or whether 

 they are brought to the tissues from some distant point in the 

 blood current, the above experiments so far afford evidence 

 that they must move in spaces which stand in direct com- 

 munication with the interior of the bloodvessels. The larger 

 the quantity of vermilion that is introduced into the blood 

 current, so much the more abundant are the corpuscles contain- 

 ing pigment discoverable in the lymph sacs of the frog. Hering 

 found that in narcotisation with opium lasting for some hours, 

 the lymph vessels of the liver became extraordinarily rich in 

 lymph corpuscles, together with red corpuscles ; and Toldt 

 observed that if insoluble anilin was simultaneously introduced 

 into the blood current, the lymph paths in the medullary sub- 

 stance of the lymphatic glands of the liver became tightly 

 packed with blue-tinted cells (admittedly without the presence 

 of free pigment granules), between which were heaps of red 

 blood corpuscles. The red blood corpuscles constantly present 

 in the lymph, and especially abundant in the chyle, were some- 

 times formerly regarded as being developed in the lymph path 

 from lymph corpuscles, but more recently they have been con- 

 sidered to enter the lymph path by rupture of the vessels. 

 According to still more recent experiments, however, show- 

 ing the permeability of the walls of the bloodvessels (see the 

 section on the bloodvessels), and the connection of the blood 

 capillaries with the serous canals, the presence of red blood 



