422 THE BLOOD, BY ALEXANDER ROLLETT. 



Forms that may be supposed to be transitional between the 

 white and the red corpuscles contained in the general mass of 

 the blood of Mammals have however been described by Erb* 

 under the term of " granular blood corpuscles/' appearing in 

 particular after artificial losses of blood. 



Kollikerf adverts to the fact that he long ago found similar 

 forms in the blood of the young sucking mouse. The mode in 

 which they originate from the nucleated white corpuscles, and 

 the stages of their conversion into the ordinary form of the red 

 blood corpuscles, still require to be systematically followed out. 

 In the blood of leucsemic patients nucleated red blood corpus- 

 cles are frequently to be found presenting the appearance of 

 the nucleated embryonic blood corpuscles of Mammals and of 

 Man. 



Reference may here also be made to the statements 

 advanced respecting the presence of red corpuscles in process 

 of development in the pulp of the spleen. (See the chapter on 

 the Spleen.) 



In the last place, attention has very recently been directed 

 by Neumann^ to the nucleated red corpuscles constantly pre- 

 sent in the medulla, and especially in the red medulla of bones 

 (Man, Rabbit) ; and Bizzozero has corroborated the obser- 

 vations of Neumann in the case of Man, the Rabbit, and the 

 Mouse. Both inquirers describe a complete series of transitional 

 forms existing between the white nucleated and the non- 

 nucleated red blood corpuscles, and associate the marrow of 

 the bones consequently with the development of the blood. 

 Still further communications on this function of the bony 

 marrow have just been made by Hoyer.|| 



* Virchow's Archiv, Band xxxiv.,p. 138, Taf. iv. 

 f Gewebelehre. 



J Centralblatt fur die medicin. Wissenschaft. Jahr., 1868, p. 689 ; and 

 Archiv fur Heilkunde, 1869, p. 640. 



Centralblatt, 1868, p. 881 ; and 1869, p. 149. 

 j| Centralblatt, 1869, pp. 244 and 257. 



