OOPHORECTOMY AND THE PITUITARY 43 



metabolism. Bernhard Fischer 1 had previously pro- 

 pounded this view. 



After careful consideration and observation I have The pituitary 

 come to the conclusion that we must look upon the organ? ° ne 

 pituitary body as one organ, and not two. In this way 

 only can we reconcile all the facts of morphology, 

 experimentation and clinical observation. The secretion 

 of the active chromophobe cells of the anterior lobe, 

 such as are seen in pregnancy, is probably not greatly 

 different from that of the pars intermedia before it is 

 altered in the way about to be described. The secretion 

 of the cells of the pars intermedia, which are develop- 

 mentally the same as those of the pars anterior, may 

 be regarded as pro-infundibulin, and it is only after 

 passing into the pars nervosa that this pro-infundibulin 

 becomes modified and acquires pressor qualities 2 . In 

 connexion with this passage of secretion into the pars 

 nervosa there are many other very important and 

 interesting facts which are not actually concerned with 

 our subject, so I refrain from discussing them here 3 . 



Next, we must come to some definite conclusion Differential 



concerning the interpretation to be placed upon the reactions of 



remarkable differences in staining properties possessed cells in tne 



pars anterior^ 

 by the cells of the anterior lobe. Although these 



variations in staining affinities are well known, I must 

 recapitulate them here in order to explain my own 

 views concerning their significance. The cells, then, of 

 the anterior portion are chromophobe or chromophil; 

 that is to say, they stain indifferently or well. The 

 chromophil cells are either eosinophil (acidophil) or 

 haematoxylinoph.il (basophil) : with eosin the cells 

 stain pink, and with haematoxylin blue. The chromo- 

 phobe cells stain lightly with haematoxylin (fig. 18). 



1 Fischer, B., Hypophysis, Akromegalie und Fettsucht, 1910. 



8 This statement was published (Lancet, 1913, vol. i, p. 814) before 

 the recent work of P. T. Herring {Quart. Joum. Exper. Physiol, 1914, 

 vol. viii, p. 245). 



8 A full discussion of the subject will be found in The Pituitary, 

 1919. 



