46 THE SEX-COMPLEX 



Hyperplasia my cats, however, definite changes were found as long 

 anterior as 245 days after oophorectomy. In these circum- 

 o5 U horec- stances, there was a large preponderance of brightly 

 tomy. stained eosinophil cells in the anterior lobe (fig. 19) — a 



condition indicating increased activity, but not the great 



activity seen after the thyroidectomy. 



In the pars intermedia the cells were fused and there 



were ' colloid ' vesicles, and sometimes ' colloid ' cysts. 



This ' colloid ' stained with eosin, in contradistinction to 



the normal condition of basophilia. 



Effects of It is interesting to note that the changes which we 



tomy on find in the pituitary after oophorectomy — that is, with 



the^ame n0t ovar i an insufficiency — are not the same as those found 



as those i n pregnancy ; consequently the relation of the pituitary 

 produced by * : f „ J ., , , , ,.., . Al . L r A , f 



pregnancy, body to the genital glands differs, m this respect at least, 



from the ovarian-thyroid relationship in similar circum- 

 stances. Fichera 1 , however, believes that the " hyper- 

 plasia and hypertrophy " which follow oophorectomy 

 resemble the condition seen in the anterior lobe during 

 pregnancy. Accordingly, this investigator thinks that 

 the change found in the anterior lobe during pregnancy 

 is due to ovarian insufficiency. As already stated, I 

 have seen nothing in my experimental results to lead 

 me to adopt this view, however plausible it may appear 

 at first sight. 



OVARIAN TRANSPLANTATION 



Ovarian Probably Knauer 2 was the first systematically to 



atrophy^ of 6n test the effects of ovarian transplantation. I have worked 



uterus after ^ ra bbits and dogs, and found, as Knauer had done, 

 oophorec- ° . 



tomy. that if the ovaries be excised and implanted in the 



muscle of the uterus or abdominal wall, atrophy of the 

 genital ducts will not occur (figs. 20 and 21). Since these 

 experiments by Knauer many observers have confirmed 

 his findings regarding the integrity of the uterus after 



1 Fichera, G., II Policlinico, 1905, vol. xii (Chir), pp. 250, 299, 319. 



2 Knauer, E., Centralbl. /. Oyndk., 1896, vol. xx, p. 524, 



