EXTRACTS OF THE PITUITARY 71 



operation was performed and the animal killed after Effect of 

 many weeks, the colloid secretion in the thyroid was £? stalk on 

 found on histological examination to be undoubtedly the th y roid - 

 excessive. Microscopically, too, the glands on removal 

 were noted to be about twice the normal size. 



EFFECTS PRODUCED BY ARTIFICIAL TUMOURS 



Paulesco 1 first conducted experiments to test the Effects of 

 effects produced by artificial tumours placed in the sella tumours in 

 turcica. He used small pieces of dried sea-sponge which bourh^od of 

 subsequently absorbed moisture and swelled. Most of the pituitary. 

 the results that followed appear to have been due to 

 pressure on the brain in the neighbourhood. 



I, also, have carried out a few experiments in which 

 I employed artificial tumours composed of sterile wax 

 impregnated with barium salts. 2 With this preparation 

 I was able to obtain radiographs showing the tumour in 

 situ (fig. 35). In the case of one animal, the radiograph 

 of whose head is shown in figure 35, there was an 

 increase of weight from 8200 grammes to 9800 grammes 

 in 57 days, and this indicated a rise in the carbohydrate 

 tolerance of the animal. Another bitch became greatly 

 emaciated, and the uterus, and ovaries and mammae 

 atrophied. Persistent glycosuria was present in this 

 animal. No changes were observed in the hormono- 

 poietic organs as the result of these experiments. The 

 interpretation of these events appears to be that if the 

 stalk be stretched or compressed by the pressure of a 

 tumour dystrophia adiposo genitalis is liable to follow. 

 On the other hand, continuous irritation with slight 

 pressure on the stalk leads to glycosuria and emaciation. 



PHYSIOLOGICAL EFFECTS OF EXTRACTS OF THE PITUITARY 



It is not possible to refer in this place to all the Effects of 

 work that has been done in connexion with the physio- the'pituitary 

 logical, and consequent therapeutical, actions of pituitary 



1 Paulesco, N. C, Ann. de Biol, 1911, vol. i, p. 221. 



2 Bell, W. Blair, Quart. Journ. Exper. Med.> 1917, vol. xi, p. 77. 



