78 



THE SEX-COMPLEX 



Excessive 

 excretion of 



Now, this increase in the calcium excretion is of very 

 caidum^fTer considerable interest, and I much regret not having a 

 removal of longer series of cases. As is well known, the view has 



one supra- . . 



renal. been advanced that osteomalacia is due to insufficiency 



of suprarenal secretion, and Bossi 1 first called attention 

 to the beneficial results to be obtained by the injection 

 of suprarenin in these cases. I shall have more to say 

 on this subject when dealing with pathological con- 

 ditions. My experiments give very strong support to 

 this view of Bossi, not only in the metabolism results, 

 but in a most striking way in regard to the bones of one 

 of these animals, in which the forelegs were found to be 

 considerably bent. Figure 36A is a skiagram of the 

 normal bones of the forelegs in the rabbit, while figure 

 36B is one showing the condition found in one of the 

 rabbits after operation. The bones of the hind legs, 

 which are thicker, were only slightly curved. It is to be 

 noted that it was in this animal that the larger quantities 

 of calcium were excreted. This is, however, an isolated 

 instance of the change in the bones, so produced, con- 

 sequently much importance must not be attached to 

 it, unless confirmation be forthcoming from further 

 experiments. It is, however, only fair to point out that 

 there was no evidence of rickets. 



Effects of 

 removal of 

 suprarenals 

 on the 

 pituitary.' 



EFFECTS OF REMOVAL OF THE SUPRARENALS ON THE 

 PITUITARY 



The changes that occur seem to be much the same 

 whether the insufficiency be acute or chronic. Thus, in 

 one cat in my series of suprarenal removals the glands 

 from both sides were removed at the same operation. 

 There was an interval of 36 hours between operation 

 and death. The cells of the pars anterior show a marked 

 degree of chromophobia with a moderate degree of faint 

 eosinophilia. In many places the nuclei are very deeply 

 stained with hematoxylin. In the pars intermedia 



1 Bossi, L. M., Centralb.f. Gynak., 1907, vol. xxxi, p. 69, 



