REMOVAL OF THE SUPRARENALE 79 



the cells are discrete — that is to say, they are not fused — Effects of 

 and show no special activity ; the nuclei stand out 8U p ra renai9 

 prominently. The pars nervosa is freely invaded by ™ the P itui " 

 the cells of the pars intermedia, but the nuclei, in which 

 there is hyperchomatosis, only are prominent, as though 

 they were left stranded after the disappearance of the 

 cell cytoplasm (fig. 37). 



Exactly similar changes were noted in the rabbit in 

 which there were such marked symptoms of chronic 

 suprarenal insufficiency, as already recorded. 



Taking all the facts into consideration we can hardly 

 come to any other conclusion than that the anterior lobe 

 shows greatly increased activity with suprarenal in- 

 sufficiency. The pars intermedia is apparently in a 

 1 used-up ', and consequently not in an actively secreting, 

 condition ; but the extensive invasion of the pars nervosa 

 by pars intermedia cells and the immediate disappearance 

 of the cell cytoplasm appear to indicate that an attempt 

 is being made to counterbalance the loss of suprarenin 

 by the rapid production of infundibulin. 



EFFECT OF REMOVAL OF THE SUPRARENALS ON THE 



THYROID 



I have been unable to trace any histological change Effect on 

 in the thyroid either in acute or chronic suprarenal in- * e * yr0 

 sufficiency. 



EFFECTS OF REMOVAL OF THE SUPRARENALS ON THE 

 OVARIES AND UTERUS 



There appears to be no histological change of im- Effects of 

 portance in the ovaries, but it is worthy of note that the ^arenais 

 normal eosinophilia of the zona pellucida is not decreased, on * he 1 . 



. », . « in genitalia. 



rather is it slightly increased. After removal of one 

 suprarenal, if insufficiency be produced, the uterus 

 appears to undergo changes comparable with those that 

 are seen after thyroidectomy, but the muscle-atrophy 

 is much less in extent ; probably this is due to the state 

 of incomplete insufficiency. 



