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His first attempts to trace degenerated nerve fibres were based upon 

 it : Minute Structure of the Papilla' of the Frog's Tongue (R. S. Phil. 

 Trans., 1849) ; Experiment* on the section of the Glossopharyngeal and 

 Hypoglossal Nerves, and Observations on the Alterations produced in 

 the structure of their primitive Fibres (R. S. Phil. Trans., 1850) ; and 

 resulted in a body of fact and doctrine that is active and growing at 

 this present day. The full account of " Wallerian degeneration " and 

 regeneration is given in a series of twelve memoirs communicated 

 to the Academie des Sciences during the years 1851 to 1856. The 

 principal paper of the series is entitled Noutelle Methode pour I'e'ttide 

 da Systeme nerveux applicable a 1' investigation de la distribution 

 anatomique des cordons nerveux. It summarizes in the briefest possible 

 manner Waller's principal contribution ; and by the single compound 

 adjective " neuro-gene-trophic," as applied to the nerve cell, clearly 

 indicates to us, as Waller's view, in the middle of the nineteenth 

 century, a doctrine that we have again received from modern observers 

 in recent times. The theory of the neurone of 1890 presents us again 

 to the neurogenetrophic cell of 1860. 



From the consideration of trophic nerve-cells Waller naturally 

 turned to the investigation of the vago-sympathetic trunk. He found 

 that after section the cephalic end of the sympathetic and the thoracic 

 end of the vagus become degenerated ; that, therefore, the trophic 

 centre of the former is below and of the latter above the point of 

 section. In collaboration with Budge, Waller, in 1851, traced back 

 the sympathetic to its origin from the spinal cord by means of the 

 action on the pupil, and defined the " cilio-spinal " region. Two 



* tOO ** of mUUmtlrt 



100 V 1 "/ miUimitrt. 



COPY OF A. WALLERS ORIGINAL FIGURE ON 

 DIAPEDESIS. 



COPY OF AN ORIGINAL PENCIL DRAWING BY 

 MRS. A. WALLER. 



