LXIV. Curare. 



1. Material. One dog; 2 frogs; sodic chloride; curare. 



2. Preparation. 



Prepare following solution of sodic chloride, 0.06 

 grms. to 10 c. c. ; curare, 0.1 grm. to 10 c. c. Pith frogs. 

 Do not fasten the dog to the board, but simply restrain 

 him. Set up inductorium and myograph, the former so 

 as to obtain single induction shocks, 

 j. Experiments and observations. 



(1) Give a hypodermic injection of 0.02 grm. curare to 

 the dog. 



(a) Record the condition of the dog just before, and 

 every ten minutes after injections of curare with 

 special reference to: 



(I) Muscular activity. 



(II) Respiration number and depth. 



(III) Circulation rate and rhythm of heart-beat. 



(IV) Which stops sooner, respiration or circula- 

 tion ? 



(3) Formulate the total effect of curare upon the 

 animal. 



(2) Ligate the thigh of a frog, except the sciatic nerve, 

 near the knee-joint. 



Inject into the dorsal lymph space 0.0012 grms. 



curare. 



(#) What elements enter into the formation of a "re- 

 flex arc?" 



() What motor phenomena would result from in- 

 creased irritability of any part of the reflex arc ? 



(<r) What motor phenomena would result from les- 



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