LXV. Atropin. 



1. Material. 2 dogs; atropin sulphate; morphin sulph- 

 ate; chloroform (or ether); mask. 



2. Preparation. Make up following solutions; a strong so- 

 lution of atropin 0.4 grm. to 10 c. c.; a weak solution, 

 0.02 grams to 10 c. c.; morphin, 0.6 grams to 10 c. c. 



Simply restrain dog " a." Fasten dog "b" to board. 

 Give hypodermically, 0.03 grm. morphin to dog " b," 

 then anaesthetize him. Set up induction coil so as to 

 obtain interrupted current, 

 j. Experiments and Observations. 



(1) Drop three drops of the stronger atropin solution 

 into one eye of dog "a," allowing them to drop in at 

 short intervals, and obstructing tear duct with pressure 

 of ringer. 



(#) What is the nerve supply of the iris ? 

 (3) On what local elements may a drug act to produce 



'alteration in size of pupil, and how ? 

 (V) Would a drug, acting centrally, though applied 



to one eye, be likely to affect one, or both pupils ? 

 (//) Would a drug, acting locally, and applied to one 



eye, be likely to affect one, or both pupils? 

 (e} Would a drug, acting locally on the pupils, but in- 

 jected into the circulation, and reaching the pupils 

 in this way, be likely to act on one, or both pupils ? 

 (/) Are either or both pupils affected by atropin, and 



if so, what effect is produced ? 



(^) Does atropin act locally or centrally to produce 

 its effect on the pupil ? 



