LXX. Aconite. 



/. Material. Tr. aconite; sulphate of atropin; 1 dog; 1 

 frog; sphygmograph. 



2. Preparation. 



Make solution of atropin, 0.02 grms. to 10 c.c. Pith 

 frog. Do not fasten the dog to the dog board. 



3. Experiments and Observations. 



(1) Give 1 c.c. tr. aconite hypodermically to the dog. 

 Record symptoms as they arise. 



(2) Fasten the pithed frog on its back to the board. 

 Count the heart beats, exposing heart, if necessary. 

 Now give 0.2 c.c. tr. aconite subcutaneously. What 

 effect has aconite on the pulse rate ? (To obtain satis- 

 factory results observations must be made at short 

 intervals, for from 30 to 60 minutes.) 



(3) After the pulse has been markedly affected, inject 

 into the dorsal lymph spaces 0.0002 grm. atropin. 

 Does atropin affect the pulse rate after administration 

 of aconite? 



(4) Take a sphygmographic tracing, of the radial 

 pulse of a student. Note the pulse rate. Administer, 

 by mouth, 0.2 c.c. tr. aconite and 0.06 c.c. every 10 

 minutes until action on pulse is noticeable. Repeat 

 tracing and counting of pulse at short intervals. 



(a) How does aconite affect blood pressure? 



(^) How is the rate of the heart's action affected? 



(<:} What subjective sensations are produced ? 



(5) Comparisons. Compare aconite and pilocarpin with 

 regard to their action on the gastro-intestinal system. 



