144 



WALTER JONES 



The four nucleotides 



The four nucleosidea 



HO\ 



O^P__0. C 5 H 8 3 .C 5 H 4 N 5 

 HO/ 



adenine nucleotide 



C,H,0 4 .C.HN. 



adenine nucleoside 



H0\ 



0=P O. C 8 H 8 8 .0 4 H 3 N a O s 

 HO/ 



uracil nucleotide 



C 5 H 9 4 .C 4 H,N,0 2 



uracil nucleoside 



HO\ 



0=P O. C B H 8 O a .0 4 H 4 N 8 

 HO/ 



cytosine nucleotide 



cytosine nucleoside 



H0\ 



0=P O . C 5 H 8 3 . C 5 H 4 N 8 

 HO/ 



guanine nucleotide 



H! OH 

 Hi OH 

 Hi OH 



C 5 H 4 .C 5 II 4 N 6 



guanine nucleoside 



The four nucleosides were prepared from yeast nucleic acid before the 

 nucleotides were known, and thus gave experimental probability to the 

 tetra-nucleotide structure of yeast nucleic acid, which up to that time had 

 been simply speculative. 



The chemistry of the nucleosides is just what one would suppose a 

 priori, and it follows closely that of the simple nitrogen derivatives. They 

 offer two possibilities, (1) hydrolysis, (2) deaminization. Thus by hy- 

 drolysis, adenosine and guanosiue are decomposed into pentose and the 

 respective purine bases. 



adenosine 



5 II 9 4 .C 5 TI 4 y 5 



guanosine 



H S = C e H I0 0. + C a II 5 Is T r> 



pentose adenine 



H 2 == C 5 H 10 G + C H B N 5 



pentose guanine 



