100 



WALTER JOXES 



The gland evidently contains adenase, guanase and adcnosine deaminase, 

 but not guanosine deaminase (Jones (6) 1011.) 



By similar experiments and similar reasoning the localization of the 

 nucleic ferments of many glands has been shown but much space would 

 be required to consider the individual cases. The general scheme of nu- 

 cleiii metabolism so far as it concerns purine derivatives, is indicated in 

 the following diagram which shows the theoretical possibilities, nucleic 

 acid being represented as a di-purine di-nucleotide. The independent ex- 

 istence of each ferment indicated by an arrow has been fairly well shown. 



H0\ /XH, 



O=P 0.0.11,0,^4011 

 HO/ \H 



H0\ I /H 



O=P~O.C 3 H 7 O^C S X 4 XH a 

 HO/ 



nucleic acid 



/OH /OH 



C 5 X 4 H OH C 5 X 4 H OH 



\OH \H 



uric acid xanthinc 



C 5 H P 4 -C R N 4 NH 3 



\H 



aclenosine 



C a H,0 4 .C 5 X 4 OH 

 \H 



Lnosine 



\H 



adenine 



'H 

 C 5 X 4 H OH 



hypoxanthine 



\H 



nthii 



