738 



HEXKY G. BARBOUR 



hydrate tolerance in this case could be varied at will by appropriate 

 changes in the dosage. (See figure 1.) On the other hand. Beard has 

 been unable to control the sugar tolerance in this fashion. .Fitz warns, 

 in this connection, that the possibility of bicarbonate edema should be 

 kept in mind. 



The hyperglycemia resulting from etherization and operative pro- 

 cedure in sugar-fed dogs was reduced by MacLeod and Fulk by injecting 



ISO 



W) 



so 



it* 



too 



Fig. 1. Influence of sodium carbonate ingestion on the glycosuria of a diabetic: 

 solid line, sugar; broken line, intake of sodium bicarbonate. (F. P. Underbill, J. 

 Am. M. Assn., 1917, LXVIII.) 



intravenously enough sodium carbonate to lower the P h of the blood. 

 (Compare Killian's results, mentioned above.) These investigators lay 

 emphasis upon increased storage of glycogen in liver and muscles, under 

 the influence of alkali. 



The influence of alkali upon renal permeability for sugar was shown 

 by the researches of Hamburger (b) upon the frog glomeruli. When the 

 perfusion fluid contained NaCl, O.G per cent; CaCL, 0.00 YS per cent; 

 KC1, 0.01 per cent; NaIICO 3 , 0.02 per cent and 0.1 per cent of glucose 

 a "urine" containing 0.07 per cent of the latter was excreted, indicating 

 a retention of 0.03 per cent. When, however, the bicarbonate content of 

 the perfusion fluid was increased to 0.285 per cent, the equivalent of the 

 normal frog serum content, a sugar-free "urine" was obtained. 



