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HEXRY G. BARBOUR 



malacia and delayed healing of fractures, establishing the therapeutic dose 

 at 1 milligram daily with meals. Cod liver oil (10 milligrams phos- 

 phorus in 100 c.c.) is often used as a vehicle. 



Jaw necrosis has been noted even with therapeutic doses. By laying 

 bare the periosteum of the jaw and other bones in rabbits which were then 

 exposed to phosphorus vapor Wegiier showed that the necrosis is due to 

 the direct action of the poison. 



Fig. 3. Same case as Fig. 2 after two years of treatment with 1/150 grain phos- 

 phorus twice daily. (D. B. Phemister, J. Am. M. Assn., 1918, LXX.) 



Definite effects of phosphorus upon the growth of normal and dis- 

 eased bones in children have been shown by Phemister, employing the 

 X-rays. Figures 2 and 3 illustrate the effects in the leg bones of a seven- 

 year-old boy with osteogenesis imperfecta. Phemister administers 1/200 

 grain pills on an average of three times a day; the deposit of compact 

 bone continues after the cessation of treatment. 



Organic Phosphorus. The alleged superiority of organic phosphorus 

 compounds has not been substantiated ; for example, Plimmer has shown 

 not only that the body can synthesize its organic phosphorus from the 



