758 HENRY G. BARBOUR 



ply of liver glycogen. Cartier associated it with intense degenerative 

 changes in the liver. He failed to find lactic acid in the urine. 



Fat Metabolism. The degenerative changes in the liver in uranium 

 intoxication have been associated by MacNider with acid poisoning. Fatty 

 infiltration of various organs is common. 



Total Metabolism and Temperature. Chittenden and Lambert found 

 the carbon dioxid output increased in uranium-poisoned dogs. This was 

 associated with some increase in body temperature. 



Chromates and Cantharidin, The toxic effects of chromates as well 

 as of cantharidin are said to resemble those of uranium. (Austin and 

 Eisenbrey.) 



Lead, Platinum, Copper, Zinc. These metals are poorly absorbed and 

 their effects upon the metabolism have received but little attention. 

 (Loewi(&)). 



Radium. Gudzent maintains that the inhalation of radioactive 

 emanations leads to an increased elimination of uric acid in the gouty, due 

 to the conversion of the lactim form of uric acid into the 1 act am. 



Contrary to these and other claims Fine and Chace(a) failed to pro- 

 duce any effect on the uric acid of the blood by radium given either intra- 

 venously or by inhalation. Berg and Welker state that radium salts given 

 per os increase both nitrogen excretion and urine volume. 



In chronic arthritis McCrudden and Sargent(&) could find no effect of 

 radium water upon the excretion of uric acid, total nitrogen or water, 

 although they state that the creatinin excretion may be affected. Recently, 

 however, Theis and Bagg in the laboratory of S. R. Benedict have pro- 

 duced a marked increase in the uric acid excretion of Dalmatian hounds 

 by intravenous injection of active deposit of radium. 



Theis and Bagg found further that the active deposit of radium in- 

 travenously injected also increased the total nitrogen output, the urea 

 curve running parallel; ammonia excretion was relatively as well as abso- 

 lutely increased. Some increase in creatinin was noted after the in- 

 creased temperature had returned to normal. 



Variable results have been observed upon the respiratory metabolism, 

 little effect having been demonstrated from the emanations. Benczur and 

 Fuchs(&) state that ingestion of 100 times the usual therapeutic dose of 

 radium has caused a 17 per cent increase in the total metabolism. Alkaline 

 radium water, on the other hand, is said to diminish the gas metabolism 

 in health but not in gout. (Staehelin and Maase.) 



According to Darms inhalation of radium causes a rise in body tem- 

 perature followed by a fall, while a fall followed by a rise is seen after 

 ingestion. 



In the treatment of lymphatic leukemia Murphy, Means, and Aub 

 foiind that radium affected the basal metabolism but slightly during the 

 marked fall in the leukocyte count. In a similar case Knudson and Erdos 



