ACETO ACETIC ESTER 8} 



BULOW, CARL, 1886. 



Ann. Chem. 236, 184-194 ; J. Chem. Soc. 52, 144 ; Jsb. Chem. 

 1886, 1515 ; Bull. Soc. chim. 47, 600. 



Phthalyl-acetoacetic Ester. 



This is obtained from phthalyl chlorid and acetoacetic ester and is 

 represented thus : 



CH 3 



CO 



C=C C 6 H 4 



I I I 



o c = o 



C0 2 C 2 H 5 



It is decomposed by sulfuric acid yielding phthalyl acetic acid. 

 Ammonia converts it into phthalyldiamid or phthalyl-imid according to 

 the temperature. Several complicated derivatives were described, 

 among them those formed by phenylhydrazin. 



KNORR, L., 1886. 



Ann Chem. 236, 290-332 ; J. Chem. Soc. 5 2 275 ; Ber. 20, 55 (C) ; 

 Jsb. Chem. 1886, 1338 ; Bull. Soc. chim. 47 811. 



Synthetical Experiments with Acetoacetic Ester. Part II. 



The first part of this article (pp. 290-317) is devoted to diaceto 

 succinic esters, the remainder to forming pyrrol derivatives from aceto- 

 acetic ester. This treated with sodium nitrite forms nitrosoacetoacetic 

 ester which mixed with acetoacetic ester and reduced, gives dimethyl- 

 pyrrol-di-carboxylic ester, C 4 NH (C H 3 ) 2 (CO 2 C 2 H 5 ) 2 [2:4:3:5]. This 

 melts at 134-! 35 and can be distinguished from its symmetrical 

 isomer by its absence of basic properties. By eliminating one of the 

 ethyl groups two isomeric mono-ethyl esters of dimethyl-pyrrol-dicar- 

 boxylic acid can be produced and from these (i) by eliminating 

 ethyl, dimethyl-pyrrol-dicarboxylic acid (2) by eliminating carbon 

 dioxid, dimethyl-pyrrol-mono-carboxylic ester. Dimethyl-pyrrol- 

 mono-carboxylic acid and dimethyl-pyrrol, C 4 N(CH 3 ) 2 H 3 , were also 

 produced. By using the anilid of acetoacetic ester corresponding 

 compounds were made and their properties described. 



