126 BIBLIOGRAPHY OF 



EMERY, W. O., 1891. 



Ber. 24, 282-286 ; J. Chem. Soc. 60, 547. 

 Action of /5-Bromopropion ic Ester on Acetoacetic Ester. 



By the action of /9-bromopropionic ester on sodacetoacetic ester, 



CH, 



CO 

 -acetylglutaric ester, CH CH 2 CH 2 CO 2 C 2 H 5 , was produced. It 



C0 2 C 2 H 5 



boils at 162 at n m. m. pressure and has a specific gravity of 1.071 at 

 20 It reacts with ammonia and with amins, yielding amido-derivatives 

 of a-ethylidineglutaric ester, which can be converted into lactams. 



HANTZSCH, A., 1891. 



Ber. 24, 495-506 ; J. Chem. Soc. 60, 739. 

 Action of Hydroxylamin on /3*=Ketonic Acids and /9-Diketones. 



By the action of hydroxylamin on acetoacetic ester in alkaline solu- 

 tion and subsequent acidification the chief product is methyl-isoxazol- 



^N O 



one, CH 3 C ' I , which melts at 169- 170 and is a base towards 

 '-CH 2 CO 



strong acids. In alkaline solutions it is partially changed into oximido- 

 butyric acid, CH 3 C : (NOH) CH 2 CO 2 H . By the action of hydroxyl- 

 amin on acetoacetic ester in neutral or acid solution, an oil is obtained 

 which, on being hydrolyzed, gives a crystalline substance, C 20 H 26 N4 

 O 7 , which melts at 140 and can by hydrolysis be changed into methyl- 

 isoxazolone. By the action of hydroxylamin on acetoacetic ester in 

 ammoniacal solution an unstable product was obtained which may be 



the hydroxamic acid of acetoacetic acid, CH 3 CO CH, C 



