CONTENTS. 



degeneration of muscles. Fatty infiltration. Intestines ; structure and 

 functions of the villi. Reabsorption and retention of the chyle. Liver; 

 intermediate interchange of matter by means of the biliary ducts. Fatty 

 liver. Fatty metamorphosis. Glands ; secretion of sebaceous matter and 

 milk (colostrum). Granule-cells and granule-globules. Inflammatory 

 globules. Arteries ; fatty usure and atheroma in them. Fatty debris. 



LECTURE XYI. A MORE PRECISE ACCOUNT OF FATTY 



METAMORPHOSIS ........ 333 



Fatty degeneration of muscles. Fatty metamorphosis of the substance of 

 the heart. Formation of fat in the muscles in distortions. Corpus lu- 

 teum of the ovary. Fatty metamorphosis of pulmonary epithelium. 

 Yellow softening of the brain. Amis senilis. Optical properties of 

 fattily degenerated tissues. Renal epithelium in Bright's disease. Succes- 

 sive stages (cloudy swelling, fatty metamorphosis, fatty detritus (debris), 

 atrophy). Inflammatory globules. Similarity of the result in inflamma- 

 tory and non-inflammatory changes. Atheromatous process in arteries. 

 Its relation to ossification. Inflammatory character of the process ; its 

 analogy with endocarditis. Formation of the atheromatous deposit. Ap- 

 pearance of cholestearine. Arterio-sclerosis. Endoarteritis. Calcifica- 

 tion and ossification of arteries. Mixed, active-passive processes. 



LECTURE XVII. AMYLOID DEGENERATION. INFLAMMA- 



TION ... ...... 409 



Amyloid (lardaceous or waxy) degeneration. Different nature of amyloid 

 substances : concentric and laminated amyloid bodies (brain, prostate), 

 and amyloid degeneration properly so called. Its course. Commence- 

 ment of the affection in the minute arteries. Waxy liver. Cartilage. 

 Dyscrasic (constitutional) character of the disease. Intestines. Kidneys: 

 the three forms of Bright's disease (amyloid degeneration, parenchyma- 

 tous, and interstitial nephritis). Lymphatic glands. Functional disturb- 

 ances of the affected organs. Inflammation. The four cardinal symptoms 

 and their predominance in the different schools: the thermic and vascu- 

 lar theory ; the neuro-pathologists, exudations. Inflammatory stimuli. 

 Lesion of function. Exudation as a consequence of the activity of the 

 tissues ; mucus and fibrine. Inflammation as a complex irritative pro- 

 cess. Parenchymatous and exudative (secretory) form. 



LECTURE XYIII. NORMAL AND PATHOLOGICAL NEW 



FORMATION ......... 4-38 



The theory of continuous development in opposition to the blastema and 

 exudation theory Connective tissue and its equivalents as the most 

 general germ-store of new formations. Correspondence between embry- 

 onic and pathological new formation. Cell-division as the most general 

 starting-point of new-formations. Endogenous formation. Physalides. 

 Brood-cavities. Different tendencies of new-formations. Hyperplasia, 

 direct and indirect. Heteroplasia. Pathological formative cells. Differ- 

 ence in their size and in the time required for their full development. 

 Description of the development of bone as a model-formation. Differ- 



