xxvi CONTENTS. 



PAGB 



ence between formation and transformation. Fresh and growing, in 

 opposition to macerated, bone. Nature of medullary tissue Growth in 

 length of tubular [long] bones ; proliferation of cartilage. Formation 

 of marrow as a transformation of tissue ; red and yellow, normal and 

 inflammatory marrow. Osseous tissue, calcified cartilage, osteoid tissue. 

 Bone-territories: caries, degenerative ostitis. Granulations in bone. 

 Suppuration of bone. Maturation of pus. Ossification of marrow. 

 Growth of long bones in thickness : structure and proliferation of the 

 periosteum. Granulations as analogous to the medulla of bones, and as 

 the starting-point of all heteroplastic development. 



LECTURE XIX. PATHOLOGICAL, AND ESPECIALLY HETE- 



ROLOGOTJS, NEW FORMATION 471 



Consideration of some forms of pathological formation of bone. Soft oste- 

 oma of the maxillae. Rickets. Formation of callus after fracture. 

 Theory of substitutive new formation in opposition to exudative. De- 

 structive nature of new-formations. Homology and heterology (malig- 

 nity). Ulceration. Mollities ossium. Proliferation and luxuriation. 

 Medulla of bones, and pus. Suppuration. Its two forms: superficial, 

 occurring in epithelium ; and deep, in connective tissue. Eroding suppu- 

 ration (skin, mucous membrane) : pus- and mucus-corpuscles in their 

 relations to epithelium. Ulcerative suppuration. Solvent properties of 

 pus. Connection of destruction with pathological growth and prolifera- 

 tion. Correspondence of the first stage in pus, cancer, sarcoma, etc. 

 Possible duration of the life of pathologically new-formed elements, and of 

 pathological new-formations considered as wholes (tumours). Compound 

 nature of the larger tuberous tumours (Geschwulstknoten), and miliary 

 character of the real foci (Heerde). Conditions of growth and recurrence : 

 contagiousness of new-formations and import of the anastomoses of cells. 

 Cellular pathology in opposition to the humoral and neuristic. General 

 infection of the body. Parasitism and autonomy of new-formations. 



LECTURE XX. FORM AND NATURE OF PATHOLOGICAL 



NEW-FORMATIONS 507 



Nomenclature and classification of pathological new-formations. Consist- 

 ence as a principle of division. Comparison with individual parts of the 

 body. Histological division. Apparent heterology of tubercle, colloid, etc. 

 Difference of form and nature : Colloid, Epithelioma, Papillary tumour, 

 Tubercle. Papillary tumours : simple (condylomata, papillomata) and 

 specific (villous cancer and cauliflower-tumour). Tubercle : infiltration 

 and granulation. Inflammatory origin of tubercle. Its production from 

 connective tissue. Miliary granules, and solitary masses. The cheesy 

 metamorphosis. Colloid : myxoma. Collonema. Mucous or gelatinous 

 cancer. Physiological types of heterologous new-formations : lymphoid 

 nature of tubercle, haematoid of pus, epithelioid of cancer, cancroid, pearly 

 and dermoid tumours, and connective-tissue-like of sarcoma. Infec- 

 tiousness according to the amount of juice. Comparison between patho- 

 logical new-formations in animals and vegetables. Conclusion. 



