378 LECTURE XV. 



sebaceous matter ; they are produced by the coalescence 

 of the minute granules which appear in the secretion of 

 colostrum. 



Now that we have seen these types of physiological 

 transformation, gentlemen, the description of the patho- 

 logical changes no longer offers any difficulty. With 

 the exception of very few structures, as for example, 

 red blood-corpuscles and the nerve-fibres in the great 

 nervous centres, nearly all other cellular parts may 

 under certain circumstances undergo a similar metamor- 

 phosis, which displays itself in a precisely similar man- 

 ner, that is, isolated, extremely minute globules of fat 

 appear in the cell-contents, become more abundant, and 

 gradually fill up the cell-cavity, without, however, run- 

 ning together into such large drops, as is the case in 

 fatty infiltration and in the adipose-tissue formations. 

 Usually, the development of the fat-granules first de- 

 clares itself at some distance from the nucleus ; very 

 seldom does it begin at the nucleus. This is the cell 

 which has long been called the granule-cell. Then 

 comes a stage, in which the nucleus and membrane are 

 indeed still to be seen, but the fat-granules lie as close 

 to one another as in colostrum corpuscles ; only at the 

 spot where the nucleus lay, there is still a little gap 

 (Fig. 66, #). From this stage there is but a short step 

 to the complete destruction of the cell. For a cell 

 never remains for any length of time in the state of a 

 granule-cell, but as soon as it has once entered into this 

 stage, the nucleus generally disappears at once, and 

 ultimately the membrane also, probably by a species of 

 solution. Then we have the simple granule- globule, or as 

 it was formerly called, inflammatory globule [exudation- 

 corpuscle], which Gluge first described under this name 

 (Fig. 66, e). 



Gluge in this made one of those mistakes which not 



