496 LECTURE XIX. 



for some time multiply excessively. The first stage is 

 then very soon followed by divisions of the cells them- 

 selves. Round about the irritated parts, where before 

 single cells lay, pairs or groups of cells are subsequently 

 found, out of which a new-formation of an homologous 

 kind (connective tissue) usually constructs itself. More 

 in the interior on the contrary, where the cells were 

 early abundantly filled with nuclei, heaps of little cells 

 soon appear, which at first 

 still preserve the direction FlG - m - 



and forms of the previous 

 connective-tissue corpus- 

 cles. Somewhat later we 

 find here roundish collec- 

 tions, or diffuse ' ' infiltra- 

 tions," in which the inter- 

 mediate tissue is extremely 

 scanty and continually liquefies * more and more, in pro- 

 liferation of the cells extends. 



If this process takes place beneath a surface which 

 does not participate in the morbid change, the layers of 

 epithelium are sometimes seen, still perfectly coherent, to 

 run over the irritated and somewhat swollen part. The 

 outermost layer of the intercellular substance is also often 

 long preserved, whilst all the deeper parts of the connec- 

 tive tissue are already filled with pus-corpuscles, are 

 " infiltrated," or " absceded " f (abscedirt). At last the 



Fig. 137. Purulent granulation from the subcutaneous tissue of a rabbit, round 

 about a ligature, a. Connective-tissue corpuscles, b. Enlargement of the corpus- 

 cles with division of the nuclei, e. Division of the cells (granulation). J, Develop- 

 ment of the pus-corpuscles. 800 diameters. 



* This liquefaction (and the same is true of the liquefaction we have described as 

 occurring in bone, p. 465) is a purely chemical process; the collagenous (gelatine- 

 yielding) substance is first transformed into mucus, and then, becoming converted 

 into an albuminous fluid, liquefies. From a MS. Note by the Author. 



f I.e . converted into an abscess. Transl. 



