Upon the Pseudo- Diphtheria , etc. 39 



leaving a slightly brownish, glistening spot which disap- 

 peared after several days. These cultures were obtained 

 during November, 1897. 



Culture 24 was obtained December 28, 1897, from secre- 

 tion of my nose, during an attack of coryza accompanied 

 with more or less fever, lassitude, headache, and vague 

 pains throughout the system. The organism appeared to 

 be in pure culture, and was found plentifully on making 

 cover-slip preparations from the secretions. Culture 25 

 was derived from the same source, a few days later. 



Cultures 26 and 27 were isolated January 4, 1898, from 

 secretions of my nose during an attack of la grippe. 

 There was a profuse muco-purulent discharge from the 

 nostrils, with acute pharyngitis and tonsilitis, some dis- 

 phagia, considerable headache, chilliness, aching of the 

 back and limbs, with considerable fever. The prostration 

 was greater than in the attack just preceding this. Along 

 with these organisms were found streptococci in consider- 

 able abundance. The nature of the symptoms and the 

 character of the discharge were markedly different from 

 those of the previous attack. Whether these differences 

 were due to the presence of the streptococcus in addition 

 to the pseudo-diphtheria bacillus, or whether they were 

 due to the streptococcus alone, or to greater virulence of 

 the pseudo-diphtheria bacillus, it is impossible to say. 



Cultures 28 and 29 were again derived from the eruption 

 on my arm, January 31, 1898, and culture 30 from my 

 nose, February 14, at the beginning of another attack of 

 la grippe. The influenza bacillus was also present in 

 large numbers, and during the attack the xerosis bacillus 

 disappeared from the secretions of the nose. Culture 31 

 was derived from the urine of Mr. H., a case of mild cys- 

 titis, April 7, 1898 ; staphylococci were also present. ' 



Morphologically, these different organisms resemble each 

 other very closely, with the exception of culture 13, which, 

 when first isolated, showed very large club-shaped bacilli 



