48 Comparative Studies 



nous fluid in the peritoneal cavity. The leucocytes in 

 this fluid contained large numbers of bacilli. The liver, 

 kidneys, lungs and adrenals were also somewhat congested. 

 The pericardial sac contained a considerable amount of 

 clear fluid. The bacilli were found in cultures made from 

 the peritoneal cavity. Cultures from all the organs re- 

 mained sterile. On section the lung shows here and there 

 small areas of infiltration. The adrenals show slight areas 

 of cell necrosis and portions of the organ seem to be 

 completely choked with blood, showing marked conges- 

 tion. Aside from the congestion nothing abnormal was 

 noted in the kidneys, liver or spleen. 



Guinea pig No. 60. Died twenty-two days after subcu- 

 taneous inoculation with 3 c. c. of an alkali-peptone bouil- 

 lon culture of 25. The animal is emaciated ; the subcu- 

 taneous lymphatics somewhat hyperaemic ; the liver dark 

 and enlarged ; the gall-bladder well filled with pale bile ; 

 the kidneys and lungs somewhat congested. The spleen 

 and adrenals appear normal. Cultures made from the 

 organs remain sterile. On section the lung shows consid- 

 erable cellular infiltration. The kidney, liver and spleen 

 are congested to a considerable extent. 



Guinea pig No. 68. Died sixteen hours after a second 

 inoculation of 3 c. c. into the peritoneal cavity of culture 

 20. Shows subcutaneous edema quite marked ; some fluid 

 in the pericardial sac ; adrenals distinctly hyperaemic ; 

 kidneys and liver congested. The retro-peritoneal glands 

 are not enlarged. Cover-slips prepared from the peritoneal 

 fluid show numerous clumps of the bacilli and many leu- 

 cocytes loaded with the bacilli. Cover-slips from the liver, 

 kidney and blood were negative. Cultures from the peri- 

 toneal fluid, liver and blood showed the bacilli. The liver 

 shows here and there rather 1 arge areas of cell necrosis. In 

 the centre of these necrotic spots there is complete disinte- 

 gration of the cellular elements. Along the margins some 

 of the cells are partially disintegrated, showing a pale 



