THE PROTEOSES 49 



at that time that peptones are absorbed as such 

 into the blood) found that the intravenous in- 

 jection of Witte's peptone, after the removal 

 of the undigested proteins from this commer- 

 cial preparation, caused in dogs striking physi- 

 ological effects. The most notable among these 

 were: (1) an inhibiting action on the coagula- 

 tion of the blood and (2) a rapid and marked 

 reduction in blood pressure. This work done in 

 Ludwig's laboratory was continued a year later 

 by Fano. Furthermore, it was shown that a 

 second injection of peptone made shortly after 

 recovery from the effects of the first had but lit- 

 tle effect. From these observations it became 

 customary to speak of " peptone poisoning" 

 and " peptone immunity. " Fano did not con- 

 fine his work to Witte's peptone, but made his 

 own product by the digestion of fibrin with pep- 

 sin and trypsin. He also used Griiber's prepa- 

 ration and one from America. Grosjean used 

 propeptone and peptone prepared by the 

 method of Kiihne and Chittenden and found 

 that the former had a marked effect, especially 

 when employed in doses of more than 0.15 g. 

 per kilo. Arthus and Huber employed caseoses 

 prepared by pancreatic digestion. Chittenden, 

 Mendel and McDermott and later Chittenden, 

 Mendel and Henderson produced highly poi- 



