PARENTERAL DIGESTION 61 



appears from the circulating fluid and carries 

 with it an appreciable amount of the proteins of 

 the blood. So far as I know Chiray is the only 

 one who has made frequent observations of the 

 effects of the parenteral administration of pro- 

 teins in man. He frequently induced albumi- 

 nuria in this way, especially in those who al- 

 ready showed renal inefficiency. In rabbits he 

 induced marked structural changes in the kid- 

 neys by repeated injections. 



In my work on the parenteral introduction of 

 proteins, I have carefully controlled the rate of 

 injection and have found that the foreign pro- 

 tein is more likely to appear in the urine when 

 the rate of injecton is high. When the protein 

 is slowly introduced, I have been surprised at 

 the large amount that can be introduced into 

 the abdominal cavity or into an ear vein with- 

 out any detectable trace appearing in the urine. 



When heterologous proteins are injected into 

 the blood they soon find their way into the in- 

 testinal lumen. They are poured in with the 

 bile and they pass into the abdominal cavity and 

 through the intestinal walls. With the biolog- 

 ical test we have detected proteins injected into 

 the ear veins of rabbits in the liver, abdominal 

 cavity and lumen of the intestines. It seems to 

 be a general physiological law that poisons in- 



