80 POISONOUS PROTEINS 



tions, some of them recorded many years ago, 

 that I do not think it incumbent upon me to 

 seek additional support. Friedberger has, in 

 a most exact way, confirmed the statement that 

 large doses of foreign protein do not, while 

 small doses do elevate the temperature. More- 

 over, he has shown that a small dose is more 

 effective in sensitized than in unsensitized ani- 

 mals. 



Thiele and Embleton have confirmed experi- 

 mentally the proposition that the parenteral in- 

 troduction of foreign proteins affects the tem- 

 perature, causing a rise or fall or having no 

 effect according to the size of the dose. They 

 give the following tables: 



EGG-WHITE. 



NORMAL ANIMAL SENSITIZED 

 Limits of grams grams 



Temperature fall 0.05 0.005 



Constant temperature 0.02 0.0002 to 0.0001 



Temperature rise 0.01 to 0.001 0.0001 to 0.000002 



TUBERCLE EMULSION. 



NORMAL ANIMAL SENSITIZED 



Limits of grams grams 



Temperature fall 0.005 to 0.002 0.0005 



Constant temperature . 0.002 to 0.001 0.0001 



Temperature rise 0.001 to 0.00001 0.00001 to 0.000001 



Criticism of the statement that foreign pro- 

 teins find certain predilection tissues in which 

 they accumulate has been made. Iodine ac- 



