PROTEIN FEVER 81 



cumulates in the thyroid gland. Mercury in- 

 duces characteristic lesions in the kidneys. 

 Strychnia selects a definite portion of the nerv- 

 ous tissue on which its action is made manifest. 

 The therapeutic effects of the most approved 

 drugs depend upon their predilection for cer- 

 tain tissues. The recent studies of Kosenow 

 indicate that bacterial proteins do not differ 

 from other poisons in this respect. We are ac- 

 customed to think of chemotaxis as acting only 

 between morphologically recognizable bodies, 

 but in reality it is a form of chemism and is de- 

 pendent upon chemical composition and not on 

 histological structure. 



The only one of the above given statements 

 formulated some years ago which has met with 

 any experimental negation is my contention 

 that specific proteases are developed by the pa- 

 renteral introduction of foreign proteins. I am 

 ready to admit that Friedberger's anaphyla- 

 toxin comes from the serum. In fact at the 

 same time that I formulated the proposition 

 concerning protein fever I wrote as follows: 

 "It has been suggested: (a) That the agar or 

 kaolin or bacteria absorb the complement from 

 the serum and that this renders it poisonous, 

 (b) That the poison is preformed in the serum, 

 but that its action is neutralized by some other 



